I'm working (slowly) on a book called What's in Your Genome?: 90% of your genome is junk! The first chapter is an introduction to genomes and DNA [What's in Your Genome? Chapter 1: Introducing Genomes ]. Chapter 2 is an overview of the human genome. It's a summary of known functional sequences and known junk DNA [What's in Your Genome? Chapter 2: The Big Picture]. Chapter 3 defines "genes" and describes protein-coding genes and alternative splicing [What's in Your Genome? Chapter 3: What Is a Gene?].Chapter 4 is all about pervasive transcription and genes for functional noncoding RNAs.
Chapter 4: Pervasive Transcription
- How much of the genome is transcribed?
- How do we know about pervasive transcription?
- Different kinds of noncoding RNAs
- Box 4-1: Long noncoding RNAs (lncRNAs)
- Understanding transcription
- Box 4-2: Revisiting the Central Dogma
- What the scientific papers don’t tell you
- Box 4-3: John Mattick proves his hypothesis?
- On the origin of new genes
- The biggest blow to junk?
- Box 4-4: How do you tell if it’s functional?
- Biochemistry is messy
- Evolution as a tinkerer
- Box 4-5: Dealing with junk RNA
- Change your worldview